Dr Shirley Li of Roche presented a poster at SBS 2009 in Lille, France describing the first use of the ForteBio Octet Red and its label-free biolayer interferometry technology for successfully completing a fragment library screening campaign for a protein target. The unique features of the system allowed for rapid screening against immobilized target, minimal protein degradation, and the sensitivity to detect the binding of small molecules in the 200 MW range.
Down load the poster from our customer presentation/poster section: http://fortebio.com/literature.html
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Octet RED system’s simple dip-and-read method allows quick assay development, has enough sensitivity to detect 200 Da fragments and sufficient throughput for rapid screening of thousands of compounds. The system does not consume target protein, and its disposable biosensors maintain protein integrity throughout the screen. A major advantage of the Octet RED is its ability to detect binding of partially precipitated samples without the complications found with microfluidics-based biosensors.
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